Lee County is a county located in the U.S. state of Florida.The county makes up the entirety of the Cape Coral-Fort Myers MSA, and is the most populous county in Southwest Florida. Lee County has the fastest growth rate in Hispanic population in the country. Its county seat is Fort Myers, and its largest city is Cape Coral. Lee County has a total area of approximately 1,212square miles of which 66% is land and 34% water. As of the 2000 census, there were 440,888 people, 188,599 households, and 127,681 families residing in Lee County, FL.